Early Detection of Sepsis

Global Impact of Sepsis

Sepsis is a life-threatening organ dysfunction caused by a dysregulated immune response to infection. The occurrence of sepsis is increasing at an annual rate of 1.5%, making it a significant global healthcare concern. Sepsis has a high mortality rate, killing more individuals than prostate cancer, breast cancer and HIV/AIDS combined.2,3,4

Importance of Early Sepsis Detection and Treatment

Despite debate over the exact timing of treatment for sepsis, it is accepted that earlier diagnosis and treatment are crucial for increasing sepsis survival rates and decreasing sepsis-related costs.3,4 Emergency Department clinicians play a unique role as the first line of care for acutely ill patients in triaging patients and initiating treatment, but identifying sepsis remains a challenge.

Because source and symptoms are often non-specific, differentiating sepsis from other types of inflammatory conditions is difficult, which can ultimately result in delayed treatment.


Lab and Clinical Sepsis Journey

When it comes to patient care, the lab is one of the foundational hospital departments that impact patients from arrival to discharge. And with so many potential touch points,
there’s an opportunity to improve patient outcomes.

WEBINAR Supporting Patient Sepsis Journeys from the Lab

Watch Dr. Tobin Efferen and Hunter Bowen’s presentation on sepsis diagnosis and management highlighting the use of standardized laboratory and clinical operations in the context of one patient’s journey from initial assessment in the Emergency Department through treatment in the Intensive Care Unit to eventual discharge.


INFOGRAPHIC Solutions that Impact Sepsis Patient

With increasing frequency, UTIs caused by ESβL-producing Enterobacterales are seen in outpatients with no previous healthcare exposures.5 Learn more about how our MicroScan panels feature drugs recommended by IDSA* and the ECDC** to treat pyelonephritis and complicated urinary tract infections caused by ESBLs.

Sepsis pathway

Although many factors contribute to the high burden of sepsis, failure to establish a prompt and accurate diagnosis is considered to be key. The challenge is that sepsis presents perniciously and variably.
Derek C. Angus, MD, MPH

Providing Data to Drive Life-saving Decisions There’s large unmet clinical need for the early detection of sepsis. Innovative diagnostic solutions can provide valuable and actionable
information to clinicians to aid in escalating and de-escalating patient care.

What is Monocyte Distribution Width?

Monocyte Distribution Width (MDW) is a regulatory-cleared, in vitro diagnostic parameter that reflects a change in circulating monocytes volume in response to pro-inflammatory signals from infectious organisms.

Clinical Lab Solutions to Provide Valuable Diagnostic Insights

Additional Resource

Beckman Coulter is proud to support the 2022 Sepsis Alliance Summit on September 28 & 29, 2022. Increase your sepsis knowledge and skills with other healthcare professionals, policymakers, and industry leaders! Learn more and register for FREE at http://SepsisSummit.org

Sepsis Alliance

1Faisal, M., et al. (2019). Computer-aided National Early Warning Score to predict the risk of sepsis following emergency medical admission to hospital: a model development and external validation study. Canadian Medical Association Journal, 191(14), E382–E389. https://doi.org/10.1503/cmaj.181418


3Jones SL et al. “Reductions in Sepsis Mortality and Costs After Design and Implementation of a Nurse-based Early Recognition and Response Program.” Jt Comm J Qual Patient Saf, vol. 41, no. 11. 2015, pp. 483–91

4Judd WR, Stephens DM, Kennedy DA. “Clinical and Economic Impact of a Quality Improvement Initiative to Enhance Early Recognition and Treatment of Sepsis.” Ann Pharmacol, vol. 48, no. 10. 2014, pp. 1269–75

5. CDC. 2019. Antibiotic Resistance Threats in the United States; https://www.cdc.gov/drugresistance/biggest-threats.html#extend

*IDSA- Infectious Disease Society of America

**ECDC- European Centre for Disease Prevention and Control